李向菲,女,博士,副教授,硕士生导师
邮箱(E-mail):xiangfeili@nufe.edu.cn
教育工作经历:
2023至今,南京财经大学,万博max在线登录,副教授;
2016.12-2022.10,南京财经大学,万博max在线登录,讲师;
(其间:2019.05-2022.12,南京农业大学,食品科学技术学院,在职博士后)
2012.09-2016.12,江南大学,食品学院,食品科学与工程,博士学位。
2009.09-2012.06,江苏大学,食品与生物工程学院,食品工程,硕士学位;
2005.09-2009.06,河南农业大学,食品科学技术学院,食品科学与工程,学士学位;
教学工作:
担任了《生物化学》、《生化实验》和《食品营养学》等专业课程的教学,并获得校级优秀教学三等奖;主持校级教改课题1项,并发表教改论文1篇;
参与建设《食品营养学》国家级一流本科课程,以及《健康食品制造》产教融合省级一流课程,《食品营养学》和《生物化学》省级在线课程。
研究领域及方向:
(1)膳食因子、肠道菌群及营养健康:通过不同的动物模型,建立肠道菌群与疾病之间的联系,挖掘食品功能因子发挥作用的潜在机制。
(2)粮食副产物精深加工与高效转化:通过创新生物法、酶法、合成生物学等多种技术手段,提取粮食副产物中多糖、蛋白、多酚和γ-谷维素等营养成分,并应用于保健品、化妆品和功能食品等中,促进粮食副产物的高值利用。
主要科研项目:
(1)国家自然科学基金委员会,青年项目,318015451007510,米糠阿魏酰低聚糖对肠道产阿魏酸酯酶菌菌群结构的调节机制研究,2019/01至2021/12。
(2)江苏省自然科学基金委员会,青年项目,SBK2018042932,基于代谢网络研究米糠阿魏酰低聚糖对肠道产阿魏酸酯酶菌菌群结构的调节机制,2018/07至2021/06。
(3)中国博士后科学基金会,面上项目,2020M671517,西兰花萝卜硫苷通过黑芥子酶/菌群系统调节机体葡萄糖转运的机制研究,2020/12至2022/07。
(4)中加食品营养与健康联合实验室,开放课题,ZJ-2020-07,基于阿魏酸酯酶代谢网络研究米糠阿魏酰低聚糖缓解氧化应激的作用机制,2020/07至2022/06。
(5)江苏省高校自然科学研究面上项目,17KJB550005,基于菌群变化解析米糠低聚糖阿魏酸酯的抗氧化机制,2017/09-2019/08。
代表性成果:
(1) Dan Shen(#), Shaotong Ma, Xiangfei Li(*), and Yingjian Lu(*). Effect of Lactobacillus with Feruloyl Esterase-Producing Ability on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice. Journal of Agricultural and Food Chemistry. 2022, 70, 14817-14830(封面论文)
(2) Weiling Guo(#), Qunran Xiang, Bingyong Mao*, Xin Tang, Shumao Cui, Xiangfei Li(*), Jianxin Zhao, Hao Zhang, and Wei Chen. Protective Effects of microbiome-derived inosine on lipopolysaccharide-induced acute liver damage and inflammation in mice via mediating the TLR4/NF-κB pathway. Journal of Agricultural and Food Chemistry. 2021, 69, 7619−7628(封面论文)
(3) Ma Shaotong(#), Pang Xinyi, Tian Shuhua, Sun Jing, Hu Qiaobin, Li Xiangfei*, and Lu Yingjian*. The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway. Food & Function, 2022, 13, 12966.
(4) Lihua Jiang(#), Xiangfei Li(#), Xinyi Zan, Xin Fu, Fengjie Cui(*), Hongan Zhu, Wenjing Sun(*), and Tinglei Tao. The β1,3glucan synthase gene GFGLS2 plays major roles in mycelial growth and polysaccharide synthesis in Grifola frondosa. Applied Microbiology and Biotechnology, 2022, 106, 563–578
(5) Junsheng Liu(#), Xiangfei Li(#), Fanfen Song, Shumao Cui, Wenwei Lu, Jianxin Zhao, Hao Zhang, Zhennan Gu, Wei Chen(*). Dietary supplementation with low-dose xylooligosaccharide promotes the anti-Salmonella activity of probiotic Lactiplantibacillus plantarum ZS2058 in a murine model. Food Research International, 2021, 15(2022), 110858
(6) Dongyan Shen(#), Qiaobin Hu, Jing Sun, Xinyi Pang, Xiangfei Li(*), Yingjian Lu. Effect of oxidized dextran on the stability of gallic acid-modifed chitosan–sodium caseinate nanoparticles. International Journal of Biological Macromolecules. 2021, 192(2021), 360-368
(7) Xiangfei Li(#), Shuhua Tian, Yunfan Wang, Jie Liu, Jing Wang, Yingjian Lu(*). Broccoli microgreens juice reduces body weight by enhancing insulin sensitivity and modulating gut microbiota in high-fat diet-induced C57BL/6J obese mice. European Journal of Nutrition. 2021, 60(7), 3829-3839
(8) Xiangfei Li(#), Lin Chen(#), Xiaoyu Zhu, Zhaoxin Lu(*), and Yingjian Lu(*). Effect of γ-aminobutyric acid-rich yogurt on insulin sensitivity in a mouse model of type 2 diabetes mellitus. Journal of Dairy Science.2020, 103(9), 7719-7729
(9) Dan Shen(#), Yingjian Lu, Shuhua Tian, Shaotong Ma, Jing Sun, Qiaobin Hu, Xinyi Pang, Xiangfei Li(*). Effects of L-arabinose by hypoglycemic and modulating gut microbiome in a high-fat diet- and streptozotocin-induced mouse model of type 2 diabetes mellitus. Journal of Food Biochemistry. 2021, 00, e13991
(更新于2024年6月21日)